DNA synthesizers are instruments used to synthesize DNA and oligonucleotides in a controlled and automated manner for various applications in molecular biology, biotechnology and therapeutics development. DNA synthesizers help accelerate the process of DNA synthesis by automating the chemical reactions involved, thereby increasing productivity and reducing human errors. They use solid-phase DNA synthesis technique where short oligonucleotides are sequentially assembled on a solid surface to form longer DNA strands of desired sequence. DNA synthesizers offer advantages like speed, precision and the capability to synthesize long DNA fragments and optimized oligos for various molecular techniques like gene cloning, gene editing and next-generation sequencing. The global demand for DNA synthesis is driven by increased research activities in life sciences and biotechnology.

The Global DNA Synthesizer Market is estimated to be valued at US$ 4.3 Bn in 2024 and is expected to exhibit a CAGR of 20.% over the forecast period 2023 to 2030.

Key Takeaways

Key players operating in the DNA Synthesizer market are Thermo Fisher Scientific, Merck KGaA, Agilent Technologies, Danaher Corporation (Integrated DNA Technologies), GenScript Biotech Corporation, Eurofins Genomics, LGC Limited, BioAutomation Corporation, Bio-Rad Laboratories, Twist Bioscience Corporation, Hamilton Company, New England Biolabs, Nippon Genetics, LGC Biosearch Technologies, DNA Script, Ribbon Biolabs GmbH, and Camena Bioscience.

The growing demand for DNA sequencing, gene synthesis and molecular diagnostics from pharmaceutical and biotechnology companies is expected to propel the growth of the DNA synthesizer market. Advances in gene therapies and personalized medicine will further augment market growth.

Technological advancements like increased synthesis scale and throughput, incorporation of artificial intelligence for automation and new platform developments are expanding the applications of DNA synthesizers in research and therapeutics development. Continuous innovations are helping address the growing needs of life science research.

Market Trends

Miniaturized DNA synthesizers: Leading manufacturers are focusing on developing compact and portable DNA synthesizers to enable on-site oligo synthesis. Miniaturized systems allow decentralized synthesis and have applications in point-of-care testing and mobile genomic services.

Adoption of continuous flow synthesis: Continuous flow DNA synthesis offers advantages like enhanced synthesis scale and throughput. Players are incorporating microfluidic technologies to develop next-gen synthesizers for industrial-scale oligo production.

Market Opportunities

Development of multi-gene DNA assembly platforms: Synthesizers capable of assembling long DNA sequences encoding multiple genes simultaneously will support advances in synthetic biology and genetic engineering applications.

Integration with artificial intelligence: Scope remains for incorporating AI and machine learning capabilities in DNA synthesizers for automated optimization of synthesis protocols, sequence design and data analysis. This can augment productivity and handle complex synthesis projects.

DNA Synthesizer market impact of Covid-19:

The COVID-19 pandemic has adversely impacted the growth of the DNA Synthesizer market in 2020 and 2021. Various factors have negatively influenced the market, such as lockdowns imposed across major countries, disruptions in the supply chain, shortage of raw materials, delays in new projects, and decline in research activities. However, with the rollout of vaccination drives globally, research activities and new projects are gradually gaining momentum. This is allowing the market to regain its lost momentum. Nevertheless, it may take some time for the market to reach pre-pandemic levels. The key players operating in the market are focusing on strengthening their supply chains and ramping up production capacities to meet the growing demand. Additionally, increasing R&D investments in vaccine development, genomics, drug discovery, and precision medicine are likely to drive the demand for DNA synthesizers going forward.

North America holds the largest share of the DNA Synthesizer market in terms of value. The presence of major players, rising R&D expenditure in life sciences, increasing research activities in synthetic biology and genomics are driving market growth in the region. The U.S. accounts for the major share of the North American DNA Synthesizer market owing to wide adoption in healthcare, pharmaceutical, and academic research verticals.

Asia Pacific is expected to be the fastest-growing regional market over the forecast period owing to large population base, improving healthcare infrastructure and increasing government spending on healthcare and life science research in countries such as China and India. Rising investments by major firms in genomics and biotechnology sectors in Asia Pacific are fostering growth opportunities. Expanding healthcare coverage, growing number of research laboratories and rising penetration of advanced technologies are fuelling market growth in the region.