Oligonucleotide synthesis involves chemical synthesis of short DNA or RNA strands that are composed of fewer than approximately 200 nucleotide monomers. Oligonucleotides are used as research tools in various applications such as PCR, sequencing and in functional genomics as well as for therapeutic application such as targeted therapies and antisense drugs. Increasing prevalence of chronic diseases such as cancer, infectious diseases and genetic disorders has fueled the research and development of novel treatment options such as gene and cell therapies using oligonucleotides. The Global oligonucleotide synthesis market is estimated to be valued at US$ 4565 Bn in 2024 and is expected to exhibit a CAGR of 13% over the forecast period 2024 to 2031.

Key Takeaways

Key players operating in the oligonucleotide synthesis market are Forte Research Systems (India), ICON plc (Ireland), Merge healthcare incorporated (U.S.), Bio-Optronics (U.S.), DSG INC (U.S.), ArisGlobal (India), ERT Clinical Bioclinica (U.S.), Oracle Corporation (U.S.), Medidata Solutions (U.S.), DATATRAK International, Inc. (U.S.), and MedNet Solutions, Inc., (U.S.) among others. These companies offer product solutions for various applications in research and clinical development.

Increasing oligonucleotide based therapies and growing interest in precision medicine offers opportunities for players in the Oligonucleotide Synthesis Market Growth. Oligonucleotides are used for treating rare genetic diseases including spinal muscular atrophy by modifying gene expressions. With rising need for targeted and personalized treatment, oligonucleotide based therapies are anticipated to witness significant growth.

The companies are expanding globally through partnerships and geographic expansion to cater to growing demand. For instance, Forte Research Systems partnered with Thermo Fisher Scientific and expanded business across U.S., Europe and Asia. The global expansion allows companies to leverage market opportunities arising due to increasing R&D spending on oligonucleotide based drugs across various regions.

Market Drivers

Growing R&D investments by pharmaceutical and biotechnology companies is a key factor driving oligonucleotide synthesis market growth. According to estimates, annual R&D spending on drug development by top 10 pharmaceutical companies increased from US$ 45 Bn in 2007 to over US$ 75 Bn in 2017. Oligonucleotides are extensively used as research tools in target identification, validation and lead optimization stages of drug development. Rising funding for development of oligonucleotide based therapeutics such as antisense, RNAi and gene therapy will further propel market growth during the forecast period.

Market Restrains

High costs associated with oligonucleotide synthesis can restrain market growth. Synthesis of longer oligonucleotides requires multi-step chemical reactions and sophisticated instruments which increases production costs. Limited success of first generation oligonucleotide drugs in clinical trials also imposes challenges. Requirement of novel delivery mechanisms to improve pharmacological properties further adds to complexity and production costs. These factors may limit widespread clinical adoption of oligonucleotide therapies.

Segment Analysis

The oligonucleotide synthesis market is segmented into reagents and consumables, equipment, and other segments. Within reagents and consumables, probes account for the largest share as they are widely used for polymerase chain reaction (PCR), gene sequencing, DNA microarrays and other molecular biology techniques. Probes segment also dominates due to rising demand for custom probes for various applications including genetic testing and molecular diagnostics.

Regional Analysis

North America dominates the oligonucleotide synthesis market due to presence of major pharmaceutical and biotechnology companies and advanced research infrastructure in the region. The market in Europe is also growing at a substantial rate driven by increasing R&D investments for development of advanced therapeutic drugs and clinical diagnostics. However, Asia Pacific is expected to witness the fastest growth during the forecast period owing to low production costs, favorable government policies to boost local manufacturing, and growing investments by market players in countries like China, Japan and India.

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